Zekiye Pelin Güven
2012-present : MSc Student, Materials Science and Engineering, Sabanci University
|Education||BSc in Materials Science and Engineering, Sabanci University,Turkey, 2012|
|Uppsala Universitat, Uppsala, Sweden, 2011.|
Separation of Nanoparticles (NP) in Multiphase Systems (MuPSs)
To be used in some biotechnology, nanotoxicology applications, obtaining purified particles from mixtures in the manner of same size, shape, etc. an important problem. Current methods to deal with this separation are insufficient (time-consuming, expensive, etc.) There is a need for a more effective method. Here is what we propose to devise a cost-effective, easy-to-use, and potentially commercializable toolbox for post-synthesis fractionation of chiral particles to obtain populations of uniform size, shape and chemistry with molecular recognition capabilities.
It has been observed that combinations of some water-soluble polymers and surfactants, settling under gravity or through centrifugation, form multiphase systems (MuPSs). The resulting system is at thermodynamic equilibrium and composed immiscible phases stacked according to their densities. These phases also exhibit different viscosities and the composition of each phase determines its chemical properties. The physical properties of the phases of a MuPS (e.g., viscosity, refractive index, ionic strength) do not necessarily correlate with density and can be tuned independently.
By tuning the chemical environment in each phase, the hydrodynamic behavior of particles in MuPSs can be affected during centrifugation. Therefore, by changing the design parameters (i.e., density, viscosity and chemical composition) of MuPSs, and the system will be tuned to achieve optimum separation of chiral particles, which are synthesized by incorporating water-soluble chiral ligands (e.g.,(S),(R)- propylene oxide ,L,D-cysteine) onto gold or silver nanoparticles.
Z.P. Guven, S. Ermez, O. Malay, Y.Z. Menceloglu, Thermo-mechanical properties of functionalized-silica/epoxy nanocomposites”,The Polymer Processing Society Regional Meeting, Istanbul, Turkey; October 20-23,2010.
|Research Areas||Nanoparticles synthesis and charactherization, biomaterials, bioseparation.|
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